![]() T1 - High-Dose Glucagon Has Hemodynamic Effects Regardless of Cardiac Beta-Adrenoceptor Blockade Registration Information URL: Unique identifier: NCT03533179.", A glucagon infusion had comparable and apparently longer-lasting effects compared with bolus, indicating that infusion may be preferable to bolus injections. Conclusions High-dose glucagon boluses had significant hemodynamic effects regardless of beta-blockade. Glucagon-induced nausea occurred in 80% of participants despite ondansetron pretreatment. Hemodynamic effects of glucagon thus reflected pharmacologic glucagon plasma concentrations. Similar effects of glucagon bolus occurred on days with beta-blockade and between 15 and 30 minutes during infusion. Compared with saline, glucagon bolus increased mean heart rate by 13.0 beats per minute (95% CI, 8.0-18.0 P<0.001), systolic blood pressure by 15.6 mm Hg (95% CI, 8.0-23.2 P=0.002), diastolic blood pressure by 9.4 mm Hg (95% CI, 6.3-12.6 P<0.001), and cardiac output by 18.0 % (95% CI, 9.7-26.9 P=0.003) at the 5-minute time point on days without beta-blockade. End points were hemodynamic and adverse effects of glucagon compared with saline. Glucagon/saline was administered from 0 minutes as a 2-minute intravenous bolus or as a 30-minute infusion (same total glucagon dose). On individual days, esmolol/saline was infused from -15 to 30 minutes. Methods and Results In a randomized crossover study, 10 healthy men received combinations of esmolol (1.25 mg/kg bolus+0.75 mg/kg/min infusion), glucagon (50 µg/kg), and identical volumes of saline placebo on 5 separate days in random order (saline+saline esmolol+saline esmolol+glucagon bolus saline+glucagon infusion saline+glucagon bolus). ![]() We therefore investigated hemodynamic effects and safety of high-dose glucagon with and without concomitant beta-blockade. Abstract = "Background Intravenous high-dose glucagon is a recommended antidote against beta-blocker poisonings, but clinical effects are unclear.
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